Smp_009990

Insulin receptor; Receptor protein-tyrosine kinase

Information

Organism: Schistosoma mansoni
Location: SM_V7_3:26041585-26079085
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Wide box showing CDS (or exon for non-coding genes) and narrow box showing UTR.

Databases

WormBase Parasite entry for Smp_009990
Sequences (WB Parasite): Gene and Gene Tree

Functions

Conserved Domain(s): FN3, FU, Furin-like, PKc_like, PTKc_InsR_like, PTZ00267, Pkinase, Pkinase_Tyr, Recep_L_domain, SPS1, STYKc, fn3 (Check domains )
GO Terms (WB Parasite): Biological Process ;  Molecular Function
KEGG Ortholog: K05087 (Orthologs in other organisms )
KEGG Pathway: AMPK signaling pathway, Adherens junction, Autophagy - animal, Breast cancer, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Focal adhesion, FoxO signaling pathway, Glioma, HIF-1 signaling pathway, Long-term depression, Longevity regulating pathway, Longevity regulating pathway - multiple species, Melanoma, Oocyte meiosis, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, mTOR signaling pathway (Details )

Gene Expression

Normalised expression of this gene in different life stages, by single-sex or mixed-sed infections, as analysed from published RNAseq studies. More information.

Data from mixed-sex infections
Created with Highcharts 12.3.0Normalised expressionChart context menuSmp_009990Gene expression throughout life stages (mixed-sex infection)Te: 11.92Te: 11.92Egg: 22.03Egg: 22.03Mir: 16.91Mir: 16.91Spo: 15.72Spo: 15.72Cerc: 35.71Cerc: 35.71Som3h: 29.87Som3h: 29.87Som24h: 32.58Som24h: 32.58m21d: 15.47m21d: 15.47m28d: 13.73m28d: 13.73m35d: 12.96m35d: 12.96m38d: 14.48m38d: 14.48m42d+: 17.04m42d+: 17.04Ov: 15.24Ov: 15.24Egg: 22.03Egg: 22.03Mir: 16.91Mir: 16.91Spo: 15.72Spo: 15.72Cerc: 35.71Cerc: 35.71Som3h: 29.87Som3h: 29.87Som24h: 32.58Som24h: 32.58f21d: 15.03f21d: 15.03f28d: 12.47f28d: 12.47f35d: 9.19f35d: 9.19f38d: 9.37f38d: 9.37f42d+: 11.43f42d+: 11.43MaleFemaleGonadEggMiraSporoCercSomule 3hSomule 24hJuvenile 21dJuvenile 28dAdult 35dAdult 38dAdult >42d102030Lu et al (2018)

Data from single-sex infections
Created with Highcharts 12.3.0Normalised expressionChart context menuSmp_009990Gene expression throughout life stages (single-sex infection)Egg: 22.03Egg: 22.03Mir: 16.91Mir: 16.91Spo: 15.72Spo: 15.72mCer: 24.90mCer: 24.90mSo1: 20.01mSo1: 20.01mSo2: 17.59mSo2: 17.59mSo3: 23.76mSo3: 23.76m18d: 14.29m18d: 14.29m21d: 15.44m21d: 15.44m28d: 13.63m28d: 13.63m35d: 12.93m35d: 12.93m38d: 13.92m38d: 13.92m42d+: 19.54m42d+: 19.54Egg: 22.03Egg: 22.03Mir: 16.91Mir: 16.91Spo: 15.72Spo: 15.72fCer: 28.78fCer: 28.78fSo1: 18.58fSo1: 18.58fSo2: 19.95fSo2: 19.95fSo3: 18.86fSo3: 18.86f18d: 12.10f18d: 12.10f21d: 16.96f21d: 16.96f28d: 13.29f28d: 13.29f35d: 11.63f35d: 11.63f38d: 13.39f38d: 13.39f42d+: 17.87f42d+: 17.87MaleFemaleEggMiraSporoCercSomule #1Somule #2Somule #3Juvenile 18dJuvenile 21dJuvenile 28dAdult 35dAdult 38dAdult >42d152025Lu et al (2018)